COURSE DIRECTOR: P. Courvalin (Institut Pasteur)

SCIENTIFIC ADVISORS: M. Gilmore (Harvard Medical School), G. Wright (McMaster University)

SCIENTIFIC COMMITTEE: G. Challis, T. Dougherty, C. Grillot-Courvalin, D. Hughes, S. Lahiri, F. Lebreton, S. Lory, A. Myers, S. Projan, H.-G. Sahl, M.-W. Tan

 

OBJECTIVE: The emergence and spread of bacteria resistant to many drug classes seriously threaten all branches of modern medicine. There is currently no course providing advanced instruction on antibiotics and resistance. The specific goal of ICARe is to bring leaders in academics and industry together with trained scientists at the dawn of their careers. Cutting-edge approaches for the study of resistance and antibiotic discovery will be examined.

COURSE: The faculty, composed of 40 internationally recognized scientists and physicians who have made important contributions to antibiotic development, infectious diseases, and resistance management will be in residence for a minimum of two days for informal interactions. Graduates will emerge with a state-of-the-art understanding of existing antibiotics: modes of action, mechanisms of resistance, approaches for mining chemical space, advancing hits to leads, the application of next-generation nucleic acid-based technologies for antibiotic discovery, and resistance detection. The course aims to build an international cadre of collaborative, well networked, and highly-trained specialists.

 

AUDIENCE: ICARe is designed for assistant professors, post-doctoral and ID fellows, new scientists from diagnostic, pharmaceutical industry, or from biotech, either working in or contemplating entering the field of antibiotics. Decision-makers involved in the discovery, development, and approval of new antibiotics, in the elaboration of programs for better use of antibiotics and reducing the development of resistance. From both the public and private sectors. Attendance will be limited to 40 students.

 

SELECTION CRITERIA: Participants will be selected by the Scientific Committee that will ensure that the participants reflect the global nature of the problem with special attention to gender equality, educational background, involvement in the field of antibiotics (research projects, scientific or industrial, which could be presented during the course are welcome), and decision-making responsibility in the finding of new antibiotics and of their appropriate use.

 

FORMAT: The course will be administered over 9 days and will consist of formal instruction and hands-on bioinformatics.

 

Application Deadline: TBD.

 

COURSE OVERVIEW
5th Interdisciplinary Course on Antibiotics and Resistance 
16 - 24 OCTOBER 2021  |  Les Pensières, Annecy, France

PROGRAM OUTLINE

ANTIBIOTIC RESISTANCE AND DISCOVERY

  • Antibiotic resistance is a global and medical problem

  • Overview of antibiotic R&D: history and strategies

  • The socio-economic challenges of antibiotic discovery

MODES OF ACTION AND MECHANISMS OF RESISTANCE OF EXISTING CLASSES

  • Cell wall: Structure, synthesis, and targets

  • Outer- and Inner-membrane: Structure and function

  • Penicillin-binding proteins, beta-lactams, beta-lactamases and inhibitors

  • Glyco-lipopeptides

  • Ribosome: Structure and function

    • Antibiotics active against the large subunit

    • Antibiotics active against the small subunit

  • Inhibitors of metabolism

  • Nucleic acid synthesis, replication, transcription: Inhibitors of type II topoisomerases, rifampicin, fidaxomicin

  • Efflux: structure-function of efflux systems and inhibitors

  • Influx-Efflux in P. aeruginosa

  • Cationic peptides

ORIGIN, MUTATIONS, & TRANSFER OF RESISTANCE 

  • Origins of resistance genes

  • Mutations, selection, biological cost, compensation

  • Mobile genetic elements

​ANTIBIOTIC DISCOVERY

  • Antibiotic chemical space in Gram-positives and -negatives

  • Antibiotic chemical matter: Natural products, synthetics

  • New approaches in natural products discovery  

  • Screens, hit generation, and hit to lead

  • Systems biology to guide antibiotic discovery and mode of action

ANTIBIOTIC DEVELOPMENT AND APPROVAL

  • Antibiotic development and approval

  • Preclinical PK/PD and optimizing leads

  • Preclinical toxicity assessment 

  • Pathways to approval and commercialization

  • New pathways to antibiotic registration

STRATEGIES FOR MORE FOCUSED APPLICATIONS OF ANTIBIOTICS

  • Targeting biofilm, virulence, site-specific delivery

  • Antibiotics under development

  • Antibiotic combinations and adjuvants


SUSCEPTIBILITY DETERMINATION AND IDENTIFICATION OF RESISTANCE MECHANISMS

  • Antibiogram: phenotypic techniques and clinical categorization

  • Rapid techniques and point-of-care diagnostics

  • Diagnostic stewardship: Optimizing the treatment of infections

  • Mass spectrometry

 

NEW ANTI-INFECTIVE STRATEGIES

  • Antibodies and engineered antibodies, vaccines, bacteriophages

  • Microbiome and antibiotics 

BIOINFORMATICS

  • Genomic epidemiology

  • Real-time sequencing of epidemic clones or resistance genes

  • Novel resistance mechanisms and the chimera of in silico antibiograms

  • Computer-guided design of novel therapeutics

  • Finding resistance genes in bacterial genomes (ResFinder and CARD)

  • Finding biosynthetic gene clusters in bacterial genomes (antiSMASH)  

  • Genome-based analysis of resistant lineages or outbreak isolates (PathogenWatch, Microreact)

  • Phylogenetic analyses of bacterial genomes (iTOL)

Due to the Covid-19 crisis, the ICARe course has been canceled for 2020 and will resume again in 2021. 

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Contact us at icarecourse@gmail.com.

© 2020 INTERDISCIPLINARY COURSE ON

ANTIBIOTICS AND RESISTANCE (ICARE)